Wegovy or Mounjaro? An Honest Comparison (2026)

These two come up side by side all the time, and it’s easy to feel stuck choosing between them. We’ve laid out how Wegovy and Mounjaro differ on the things that actually shape your day-to-day — results, cost, how you take them, and how they tend to feel — so you can head into your next appointment with a clear question instead of a guess.

The quick answer

In short: Wegovy (Semaglutide) helps people lose around 15–17% of their body weight at roughly $1,349/mo, while Mounjaro (Tirzepatide) averages about 15–22% at roughly $1,023/mo. Neither is a clear winner for everyone — what tips the scale is your goals, what your insurance covers, and how your body takes to it.

The two, side by side

Feature	Wegovy	Mounjaro
Active ingredient	Semaglutide	Tirzepatide
Drug class	GLP-1 receptor agonist	Dual GLP-1/GIP receptor agonist
Manufacturer	Novo Nordisk	Eli Lilly
FDA approved for	Chronic weight management + CV risk	Type 2 diabetes
Approval year	2021	2022
Doses	0.25mg to 2.4mg weekly	2.5, 5, 7.5, 10, 12.5, 15 mg
Administration	Weekly injection (pen) · oral pill option	Weekly injection (pen)
Avg. weight loss	15–17%	15–22%
A1C reduction	1.5–1.8%	1.9–2.4%
Monthly cost (list)	$1,349	$1,023
Oral available	Yes	No

Prices shown are typical self-pay list costs without insurance. Seed data — please verify before relying on it.

Wegovy

15–17%

avg. body-weight loss

The same medicine as Ozempic, dosed higher and approved specifically to help you lose weight. There's now an oral pill version too, if needles aren't your thing.

$1,349/mo list price

Mounjaro

15–22%

avg. body-weight loss

A weekly tirzepatide shot for type 2 diabetes that works on two hunger pathways at once, which is why trial participants tend to see some of the biggest average weight loss of any option.

$1,023/mo list price

Wegovy might be your match if…

Your plan covers it but not Mounjaro — let coverage lead.
A longer track record puts you at ease (it’s been around since 2021).
You’re already doing well on Semaglutide and would rather not switch.

Mounjaro might be your match if…

The strongest possible weight loss is your top priority (15–22%).
You’re drawn to its dual glp-1/gip receptor agonist approach.
Your plan covers Mounjaro (or its weight-loss version).

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Questions people ask us about these two

Often, yes — but it's a move to make with your doctor, not on your own, especially since these use different active ingredients (Semaglutide vs Tirzepatide). Your prescriber will set a sensible starting dose and step you up gradually so your body has time to adjust.

In studies, Wegovy averages about 15–17% of body weight and Mounjaro averages about 15–22%. Those are averages, though — your own results hinge on your dose, your habits around food and movement, and your metabolism, so treat the numbers as a guide rather than a promise.

At full list price, Wegovy runs roughly $1,349/mo and Mounjaro about $1,023/mo. But list price is rarely what people actually pay — once insurance, manufacturer savings, or a cash-pay program enter the picture, your real cost can look very different.

They're cut from the same cloth, so both can bring on stomach-related effects like nausea, diarrhea, or constipation, usually most noticeable early on as your dose climbs. How strong those effects feel can differ from person to person, which is one more reason to talk through your history with your doctor.

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